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Cited by 112 articles. Novel In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Several pathways that regulate telomere length have been identified, and genome-scale studies have helped in mapping genes that are involved in telomere length control. Additionally, the nature of telomerase regulation is currently only poorly understood.

In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Telomerase reactivation in malignant cells after genomic instability causes cancer progression. Inhibiting telomerase caused tumor cell death but also led to alternative lengthening of telomeres (ALT) independent of telomerase. In this model, telomerase activation occurs after the selection of mutations that stimulate abnormal cell proliferation, and, thus, telomerase activation may be a relatively late event in tumor initiation that allows for genome stability after the acquisition of cancer-associated mutations. It is believed that cancer occurs because a genetic mutation can trigger the production of an enzyme, known as telomerase, which prevents telomeres from shortening.

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Telomerase has functions not only to extend telomere length but also to repair DNA damage. Studies have shown that telomerase may increase cancer cell resistance to DNA-damaging anticancer agents; tamoxifen may suppress telomerase expression in breast cancer cells.

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2021-03-07 · Telomerase and Cancer Cancer cells multiply rapidly, which would normally result in shortened telomeres. Cancer cells make telomerase, however, preventing the telomeres from becoming so short that the cells can no longer survive. It is well known that a decreased expression or inhibited activity of telomerase in cancer cells is accompanied by an increased sensitivity to some drugs (e.g., doxorubicin, cisplatin, or 5-fluorouracil). However, the mechanism of the resistance resulting from telomerase alteration remains elusive. There are theories claiming that it might be associated with telomere shortening, genome 2020-05-01 · The telomerase holoenzyme, which has a highly conserved role in maintaining telomere length, has long been regarded as a high-profile target in cancer therapy due to the high dependency of the majority of cancer cells on constitutive and elevated telomerase activity for sustained proliferation and immortality. Telomerase activity or a mechanism to maintain telomere stability is necessary for the continued proliferation of cells and is a critical, perhaps rate-limiting, step in cancer progression. Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, developing specific anticancer therapies remains a challenge.

Activating telomerase in cancer cells Jul 30, 2020 Telomeres and cancer cell immortality. Telomere maintenance and cell immortality by telomerase.
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The enzyme has recently been found in many human tumors and is being eyed as a new target for cancer therapy Longer telomeres will afford cancer cells additional divisions during which mutations can creep into the genetic code, including mutations that activate telomerase. Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, developing specific anticancer therapies remains a challenge. The recently discovered relationships identified among telomeres, telomerase, aging, and cancer have opened a new avenue in tumor biology research that may revolutionize anticancer therapy. This review summarizes the critical aspects of (A) Survival curve summarizing data from mouse models examining the role of telomerase and telomere length in cancer-related survival. It shows a survival advantage for short-telomere mice in a model of Myc-induced lymphoma, according to Feldser et al.

E. Miri-Moghaddam & A. Deezagi & Z. S. Soheili.
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Identification of seven loci affecting mean telomere length and

Ultimovacs is performing a broad clinical development program with clinical trials in av B Ujvari · 2016 · Citerat av 31 — Cancer is an evolutionary and ecological process in which complex However, genomic 7, epigenomic 11, telomere homeostasis 12 and Hitta perfekta Cancer Genomics bilder och redaktionellt nyhetsbildmaterial hos Getty Images. Välj mellan 201 premium Cancer Genomics av högsta kvalitet. Morus Rubra Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells Through Endoplasmic Reticulum Stress and Telomerase.